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KMID : 0360220090500030424
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Journal of the Korean Ophthalmological Society
2009 Volume.50 No. 3 p.424 ~ p.428
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The Effect of Dorzolamide-Timolol and Latanoprost on Redox Cycle in Aqueous Humor of Rabbit
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Park Sang-Woo
Lee Seung-Hyun
Mun Gwi-Hyeong
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Abstract
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Purpose: To evaluate the effect of dorzolamide-timolol and latanoprost on redox cycle of superoxide dismutase (SOD) and ascorbic acid in the aqueous humor of the rabbit.
Methods: Group 1 (20 eyes of 10 rabbits) was instilled with dorzolamide-timolol in the right eye and Group 2 (20 eyes of 10 rabbits) was instilled with latanoprost in the same manner. Four weeks after instillation, SOD activity and ascorbic acid concentration were analyzed.
Results: In Group 1, SOD activity and ascorbic acid concentration of the right eye and left eye were 15.7% and 19.3% (p=0.27), 2.7 pM and 2.6 pM (p=0.47), respectively. In Group 2, SOD activity and ascorbic acid concentration of the right and left eye were 22.3% and 27.6% (p=0.14), 2.3 pM and 2.1 pM (p=0.89), respectively.
Conclusions: There was no significant difference of SOD activity and ascorbic acid concentration between both eyes in Group 1 and 2.
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KEYWORD
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Ascorbic acid, Dorzolamide-timolol, Latanoprost, Superoxide dismutase
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